(R)-(+)-THALIDOMIDE[干冰运输]

Name	(R)-(+)-Thalidomide
Synonyms	(R)-(+)-Thalidomide (R)-(+)-THALIDOMIDE 6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid (+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide 6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2 (3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione (R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE (+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione
CAS	2614-06-4

Molecular Formula	C13H10N2O4
Molar Mass	258.23
Density	1.2944 (rough estimate)
Melting Point	269-271°C
Boling Point	401.48°C (rough estimate)
Solubility	DMSO: soluble
Appearance	Solid
Color	white
pKa	10.70±0.40(Predicted)
Storage Condition	-20°C Freezer
Refractive Index	1.5300 (estimate)
In vitro study	The transport of the (R)-Thalidomide from the R-imprinted MIP-1 through the donor phase to the receiver phase is much less owing to the stronger retention of the thalidomide in the organic phase. With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities. The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs.
In vivo study	Adult female F344 rats are implanted with 9L gliosarcoma tumours intracranially, subcutaneously (flank), or both. Effectiveness of oral thalidomide alone, and with intraperitoneal BCNU or cisplatin combination chemotherapy, is assessed after several weeks treatment. Both serum and tissue concentrations of (R)-thalidomide are 40-50% greater than those of (S)-thalidomide. Co-administration of BCNU or cisplatin with thalidomide did not alter the concentration enantioselectivity.

Hazard Symbols	T - Toxic
Risk Codes	R61 - May cause harm to the unborn child R22 - Harmful if swallowed
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany	3
RTECS	TI4925000

biological activity

(R)-thiidomide ((R)-( )-thiidomide) it is the R-enantiomer of thridomide. (R)-thiidomide has a sedative effect.

Last Update：2024-04-09 20:02:46

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